272. Understanding Depression VI: Ancient Wisdom and Modern Science

The OptimalWork Podcast

#272: In this episode, Sharif and Kevin continue their exploration of depression, burnout, and low energy—this time uncovering a remarkable bridge between neuroscience and classical wisdom. Kevin reveals how adenosine’s “good tired” and “bad tired” states map directly onto Aquinas’ ideas of tristitia and acedia, showing that what medieval thinkers called “weariness of soul” may be the same state modern science calls burnout or depression. Together, they unpack Aquinas’ five treatments for sadness—pleasure, friends, contemplation, sleep, and tears—and show how each one perfectly targets a modern neurobiological pathway of vitality, meaning, effort, and attention. Find more at https://OptimalWork.com

About Podcast

Hosted by Dr. Kevin Majeres and Sharif Younes, co-founders of OptimalWork, The OptimalWork Podcast will help you learn to challenge yourself in each hour of work according to your highest ideals. We discuss all aspects of Dr. Majeres's approach to work, which he developed in his private practice and teaches at Harvard Medical School, and show how it applies to everyday situations like professional work, study, sleep, and relationships.

For personalized plans to help you put the ideas into practice, visit www.OptimalWork.com.

Please send questions for discussion to team@optimalwork.com.